Diisopropylethylamine → HCID 86590193, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 278 (3.6 g, 9.57 mmol), aminoacetonitrile bisulfate (2.94 g, 19.12 mmol) and N,N-diisopropylethyl-amine (3.5 ml) in DMF (60 ml) was stirred under Ar at 55° C. for 16 h. After evaporation of solvent, the residue was separated by chromatography on silica gel eluted by CHCl3-ethyl acetate (10:1) to give g of compound 279. MS (ESI) 247.12 (M−H+). H1-NMR (DMSO-d6) 9.16 (t, 1H), 8.26 ((d, 1H), 7.49 (d, 1H), 4.28 (d, 2H), 4.23 (d, 2H), 1.30–1.28 (m, 1H), 0.50–0.46 (m, 2H), 0.41−0.38 (m, 2H).

Provenance & Evidence