HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Bromide → 6-Ethoxy-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6-Hydroxyindole | HCID 524508 | — |
| Product | 6-Ethoxy-1H-indole | HCID 526769 | — |
Reaction Steps
6-Hydroxyindole (1.0 equivalents) is dissolved in dry, degassed acetone. EtBr (5.0 equivalents) and Cs2CO3 (2.5 equivalents) are added, and the resulting solution is stirred for 18 hours. The reaction mixture is filtered through a Celite plug. The solvent is evaporated, and the product is purified by flash chromatography (MeOH:CH2Cl2, 5:95) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064215B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-6e79d5159bfa4d34a2e0a6e0d968f43b |
| Source note | uspto-grants-2006_06 |