反应详情

温度

130 °C

{[1,4-bisbenzylpiperazin-2-yl]methyl}dimethylamine (1 equivalent), was dissolved in EtOH and the solution was transferred to a stainless steel high pressure vessel equipped with a pressure gauge. 10% Pd/C was added (10 wt. %), and the vessel charged with H2. The reaction mixture was stirred at 130° C. and 200 psi of H2 overnight. The reaction mixture was cooled to room temperature, filtered over a pad of Celite, and then evaporated. The desired amine was obtained in quantitative yield as a pale yellow oil. GC/MS: 143 (10%, M+), Rt=14.3 minutes.

1. customthe solution was transferred to a stainless steel high pressure vessel
2. customequipped with a pressure gauge
3. additionthe vessel charged with H2
4. custom200 psi of H2 overnight
5. temperatureThe reaction mixture was cooled to room temperature
6. filtrationfiltered over a pad of Celite
7. customevaporated