Acetic Anhydride → HCID 22056091, compound

Participants

Reaction Steps

4-(1-methyl-3-piperidyloxy)phenylamine (1 equivalent) was dissolved in CH2Cl2 and a catalytic amount of DMAP was added. Acetic anhydride (1.3 equivalents) was added slowly, and the solution was stirred at room temperature overnight. The reaction was then quenched with water and the aqueous layer was extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4 and concentrated in vacuo, to yield N-[4-(1-methyl-3-piperidyloxy)phenyl]acetamide as a yellow oil. LC/MS (m/z) 249.3 (MH+), Rt 1.24 minutes.

Provenance & Evidence