2-Pyridinemethanamine → HCID 10189047, compound

HRID 1830087Notes

Reaction equation

[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[CH:6][C:5]([O:17][CH3:18])=[C:4]([C:19]([N:21]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[CH2:25][N:24]3[C:32]([C:35]([OH:37])=O)=[CH:33][CH:34]=[C:23]3[CH2:22]2)=[O:20])[CH:3]=1.[NH2:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[CH:6][C:5]([O:17][CH3:18])=[C:4]([C:19]([N:21]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[CH2:25][N:24]3[C:32]([C:35]([NH:38][CH2:39][C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=4)=[O:37])=[CH:33][CH:34]=[C:23]3[CH2:22]2)=[O:20])[CH:3]=1

Participants

Reactant 2

HCID 195092-Pyridinemethanamine

HCID 10142600HCID 10142600, compound

Product 1

HCID 10189047HCID 10189047, compound

Procedure

Prepared by coupling the 10-{[6-chloro-3-methoxy-2′-ethoxy-[1,1′-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of Step C with 2-(aminomethyl)pyridine (1.25 equiv.) in the manner of Example 1.

Workup

customPrepared

Sources & evidence

ORD record: ord-1710b85f1dd247a0885925004d1dde9c
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07064120B2

Reaction notes

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