Ethanol → HCID 22053927, compound

Participants

Reaction Steps

3-Benzylsulfanyl-2-benzylsulfanylmethyl-propionic acid ethyl ester (1.589 g, 4.41 mmol) in a mixture of potassium hydroxide (1N, 7 mL), water (3 mL), dioxane (30 mL) and ethanol (10 mL) was stirred at room temperature for 18 hours. The solvents were removed form the reaction mixture by rotary evaporation at reduced pressure and the residue was dissolved in water and washed with ether. The aqueous layer was cooled on ice, acidified to pH 2 and the product extracted with ethyl acetate. The extracts were washed with saturated aqueous sodium chloride and then dried over magnesium sulfate. The solvent was removed by rotary evaporation at reduced pressure to give 3-benzylsulfanyl-2-benzylsulfanylmethyl-propionic acid (1.293 g, 88%).

Provenance & Evidence