Methanol → HCID 22054074, compound

Participants

Reaction Steps

4-(4-Methylsulfonylamino-phenyl)-2-methylene-4-oxo-butyric acid (800 mg, 2.83 mmol) was dissolved in DMF (5 mL). Benzyl mercaptan (0.5 mL, 4.25 mmol) and DMAP (200 mg, 1.6 mmol) were added. The mixture was stirred at ambient temperature for 16 hours. Methanol (200 mL) was added and, under vigorous stirring, a saturated aqueous solution of Oxone® (15 g, 24.4 mmol) was added in one portion. Stirring was continued for 2 hours. Methanol was removed under vacuum and the aqueous residue was diluted with 100 mL water. The crystallized product, 4-(4-Methylsulfonylamino-phenyl)-4-oxo-2-benzylsulfonylmethyl-butyric acid (380 mg), was filtered, washed with water, and dried under vacuum.

Provenance & Evidence