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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1830149Generated: October 30, 2026

Water → 3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid

https://huagongshe.com/reaction/1830149

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantSodium HydroxideHCID 14798—
Reactant3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid ethyl esterHCID 69438454—
SolventEthanolHCID 702—
Product3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acidHCID 22053950—

Reaction Steps

A solution of 3-benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid ethyl ester (1.27 g) in ethanol (30 ml) was treated with 2N NaOH (9.4 ml) overnight. Usual water work up gave the title compound as white solid; MS: 333 (M+Na), 311 (M+1); LCMS retention time 3.7 minutes.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07064123B1
Source datasetuspto-grants-2006_06
ORD IDord-a1817138339f41fa8c8249f27ff5796d
Source noteuspto-grants-2006_06