HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Benzylsulfonyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid | HCID 22053950 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Benzylsulfonyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid | HCID 22053974 | — |
Reaction Steps
A solution of 3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid (1.16 g, 3.7 mmol) in a mixture of MeOH (10 ml) and water (30 ml) was treated oxone (3.5 g, 5.6 mmol) overnight. Methanol evaporated off under reduced pressure, aqueous layer extracted with ethyl acetate, dried (Na2SO4) and evaporated under reduced pressure to give the title compound as white solid (1.36 g); MS: 365 (M+Na), 343 (MH+); LCMS retention time 3.1 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064123B1 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-1b94bcd4e5f7488487ffaebaa4282f5a |
| Source note | uspto-grants-2006_06 |