HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-Methylene4-morpholin-4-yl-4-oxo-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Itaconic Anhydride | HCID 75110 | — |
| Product | 2-Methylene4-morpholin-4-yl-4-oxo-butyric acid | HCID 22054022 | — |
Reaction Steps
Morpholine (20 mL, 228.6 mmol) was slowly added to a stirring solution of itaconic anhydride (25.1 g, 228.6 mmol) suspended in dichloromethyl at 0° C. The reaction mixture was allowed to slowly warm to room temperature. Upon completion (LCMS), volatiles were removed by vacuum under reduced pressure. Crude yield: 44.96 g, 99%. Product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064123B1 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-27bb447413a449bf8ea04c9247f4c314 |
| Source note | uspto-grants-2006_06 |