Hydrochloric Acid → 2-Amino-1-benzooxazol-2-yl-butan-1-one hydrochloride

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Reaction Steps

Hydrogen chloride in dioxane (1M, 1 ml) was added to a solution of, 1-(Benzooxazole-2-carbonyl)-propyl]-carbamic acid tert-butyl ester (2a) in dry methylene chloride (3 ml) and stirred at room temperature for 4 hrs. Concentration under reduced pressure gave the title compound as white solid (65 mg); 1H NMR (CDCl3) δ 0.99 (t, J=7.5 Hz, 3H), 2.20–2.05 (m, 2H), 4.96 (m, 1H), 7.58 (t, J=7.4 Hz, 1H), 7.69 (t, J=7.4 Hz, 1H), 7.94 (d, J=8.2 Hz, 1H), 8.04 (d, J=8.2 Hz, 1H), 8.75 (m, 3H); MS: 207(MH+).

Provenance & Evidence