1,2-Dichloroethane → HCID 22054038, compound

Participants

Reaction Steps

To a stirred mixture of 4-morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acid (142 mg, 0.4 mmol), 2-amino-2-methyl-1-oxazolo[4,5-b]pyridin-2-yl-propan-1-one TFA salt (165 mg), prepared as in reference 14, and HOBt (73 mg, 0.45 mmol) in MeCl2 (5 ml) was added EDC (115 mg, 0.6 mmol) and N-methylmorpholine (0.25 ml) at room temperature. After stirring for 14 hours, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated NaHCO3, brine, dried with MgSO4 and concentrated. The residue was purified by silica gel column chromatography to yield 92 mg of N-{1-[(5-Ethyl-[1,3,4]oxadiazol-2-yl)-hydroxy-methyl]-butyl}-4-morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyramide.

Provenance & Evidence