1,2-Dichloroethane → HCID 22054066, compound

Participants

Reaction Steps

To a stirred mixture of 4-morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acid (177 mg, 0.5 mmol), 2-amino-1-(5-phenyl-[1,3,4]oxadiazol-2-yl)-1-butanol TFA salt (175 mg), prepared as in reference 17, and HOBt (92 mg, 0.6 mmol) in MeCl2 (5 ml), was added EDC (144 mg, 0.75 mmol) and N-methylmorpholine (0.35 ml) at room temperature. After stirring for 14 hours, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated NaHCO3, brine, dried with MgSO4 and concentrated to yield 308 mg of N-[1-(Hydroxy-oxazolo[4,5-b]pyridin-2-yl-methyl)-propyl]-4-morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyramide; MS: 543.6 (M−1), 545.6(M+1)

Provenance & Evidence