(R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acid → (R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-N-[(S)-1-(3-phenyl-1,2,4-oxadiazole-5-carbonyl)-propyl]-butyramide

HRID 1830201Notes

Reaction equation

HRID 1830201 reaction equation
[CH:1]1([CH2:7][C@H:8]([CH2:12][C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][CH:22]([CH2:36][CH3:37])[C@@H:23]([C:25]1[O:29][N:28]=[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:26]=1)[OH:24]>>[CH:1]1([CH2:7][C@H:8]([CH2:12][C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[C:9]([NH:21][C@H:22]([C:23]([C:25]2[O:29][N:28]=[C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[N:26]=2)=[O:24])[CH2:36][CH3:37])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 59972959(R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acidHCID 68824651(S)-2-Amino-1-(3-phenyl-1,2,4-oxadiazol-5-yl)-butan-1-ol

Product 1

HCID 58649541(R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-N-[(S)-1-(3-phenyl-1,2,4-oxadiazole-5-carbonyl)-propyl]-butyramide

Procedure

Similarly prepared according to the general procedure given for Example 43 above but using (R)-2-cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acid and (S)-2-amino-1 (3-phenyl-[1,2,4]oxadiazol-5-yl)-butan-1-ol; MS: 497 (MH+).

Workup

  1. customSimilarly prepared

Sources & evidence

ORD record
ord-de34a46cdc94441381c45ed8450c1bcc
Source dataset
uspto-grants-2006_06
Patent number
US07064123B1

Reaction notes

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