反应详情

Methyl 5-(3,4,5,6-tetramethoxy-2-methylbenzyl)-2-hydroxybenzoate (1.09 g, 2.53 mmol) was dissolved in acetone (50 ml) and after adding thereto anhydrous sodium carbonate (0.420 g, 3.03 mmol) and tert-butyl bromoacetate (0.592 g, 3.03 mmol), the solution was refluxed under heating for 3 hours. The reaction solution was filtered, the filtrate was concentrated, and the obtained residue was purified by silica gel column chromatography (hexand:ethyl acetate=2:1) to obtain the titled compound (0.650 g, 1.33 mmol, 53%).

1. additionafter adding
2. temperatureunder heating for 3 hours
3. filtrationThe reaction solution was filtered
4. concentrationthe filtrate was concentrated
5. customthe obtained residue was purified by silica gel column chromatography (hexand:ethyl acetate=2:1)