Dichloromethane → HCID 21031078, compound

Participants

Reaction Steps

(R)-Phenethylamine (0.162 g, 1.337 mmol), dimethylaminopyridine (0.016 g, 0.134 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.384 g, 2.005 mmol) were added to a methylene chloride solution (30 ml) of 5-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-yl)methyl-2-acetoxybenzoic acid (0.250 g, 0.668 mmol) and the resulting solution was stirred at room temperature for 12 hours. The reaction solution was poured into ice water and then extracted with methylene chloride. The extract was washed with water and then dried, and the solvent was removed by distillation. The obtained residue was purified by preparative thin-layer chromatography (hexand:ethyl acetate=2:1) and then recrystallized from ether to obtain the titled compound (0.167 g, 0.350 mmol, 52%).

Provenance & Evidence