Toluene → HCID 22045224, compound

Participants

Reaction Steps

To 200 ml of toluene was added 8.2 g of (2-propyl-1,8-difluorofluorenyl)boric acid (K-5), 7.4 g of p-iodotoluene, 31 ml of 2M aqueous sodium carbonate, 0.5 ml of ethanol and 1.0 g of tetrakis(triphenylphosphine)palladium, and the mixture was refluxed under heat for 20 hours. The reaction mixture was then washed sequentially with water and a saturated aqueous solution of sodium chloride, dried, and then purified by silica gel chromatography to yield 7.1 g of 7-(4-methylphenyl)-2-(n-propyl)-1,8-difluorofluorene (II-I1).

Provenance & Evidence