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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18305Generated: October 25, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 7-fluoro-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/18305

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Reactant7-Fluoro-1H-indole-3-carbaldehydeHCID 22139120—
Product7-fluoro-3-(methylaminomethyl)-1H-indoleHCID 2213905990%

Reaction Steps

According to the procedure of Preparation 13 (c), except substituting 7-fluoro-1H-indole-3-carboxaldehyde (0.5 g, 3.1 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.5 g, 90%) was prepared as a viscous oil: MS (ES) m/e 179 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-3dfcd3713ab54d4dbb92fdd1ba5cee99
Source noteuspto-grants-2010_06