2-(Bis(methylsulfanyl)methylidene)propanedinitrile → HCID 9855798, compound

HRID 1830572Notes

Reaction equation

HRID 1830572 reaction equation
CS[C:3](=[C:6]([C:9]#[N:10])[C:7]#[N:8])[S:4][CH3:5].[NH2:11][C:12]1[CH:16]=[CH:15][NH:14][N:13]=1>C(O)C>[NH2:8][C:7]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[N:11]=[C:3]([S:4][CH3:5])[C:6]=1[C:9]#[N:10]

Participants

4

Reactant 2

HCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 178418806HCID 178418806, compound

Product 1

HCID 9855798HCID 9855798, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.3 g of bismethylthio methylenepropane dinitrile, 5.0 g of 3-aminopyrazole and 250 ml of ethanol were stirred under reflux with heating for about 6 hours and then cooled to room temperature, and the precipitated crystals were collected by filtration. The collected crystals were washed with ethanol and then dried to obtain 10.9 g of 7-amino-5-methylthiopyrazolo[1,5-a]pyrimidine-6-carbonitrile (compound No. 1) having a melting point of at least 240° C.

Workup

  1. temperatureunder reflux
  2. temperaturewith heating for about 6 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe collected crystals were washed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-6c1760be0b6941ab8fa6be1d184ae29a
Source dataset
uspto-grants-2006_06
Patent number
US07067520B2

Reaction notes

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