Water → HCID 69641041, compound

Participants

Reaction Steps

In 18 ml of toluene, 0.51 g of 4-hydroxy-6-methyl-2-oxo-2H-pyrane-3-carboxylic acid, 0.67 g of 2-methyl-2-propanol and 0.07 g of 4-dimethylaminopyridine were dissolved, and 0.58 g of WSC was added and the mixture was stirred at room temperature for 16 hours. Subsequently, water was poured into the reaction mixture, and the reaction mixture was extracted with ethyl acetate. The resultant organic layer was washed with a saturated solution of sodium chrolide, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was subjected to a silica gel column chromatography to obtain 0.22 g of tert-butyl 4-hydroxy-6-methyl-2-oxo-2H-pyrane-3-carboxylate (Compound No. 7).

Provenance & Evidence