tert-butyl N-(prop-2-yn-1-yl)carbamate → HCID 22048127, compound

HRID 1830594Notes

Reaction equation

HRID 1830594 reaction equation
[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([NH:15][C:16]2[CH:21]=[CH:20][C:19](I)=[CH:18][CH:17]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:23]([O:27][C:28]([NH:30][CH2:31][C:32]#[CH:33])=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([C:33]#[C:32][CH2:31][NH:30][C:28]([O:27][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:29])=[CH:18][CH:17]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11073648tert-butyl N-(prop-2-yn-1-yl)carbamateHCID 22048121HCID 22048121, compound

Product 1

HCID 22048127HCID 22048127, compound

Procedure

Using an analogous procedure to that described in Example 37, starting from 4-anilino-5-bromo-2-(4-iodoanilino)pyrimidine (Method 12) and 3-(t-butoxycarbonylamino) propyne, the product was obtained. NMR: 1.4 (s, 9H), 3.9 (d, 2H), 7.1–7.3 (m, 4H), 7.4 (m, 2H), 7.6 (m, 4H), 8.2 (s, 1H), 8.6 (s, 1H), 9.5 (s, 1H); MS (MH+): 494.3, 496.3.

Workup

  1. customthe product was obtained

Sources & evidence

ORD record
ord-9699651d076c48f69ac729f6faf71ce0
Source dataset
uspto-grants-2006_06
Patent number
US07067522B2

Reaction notes

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