Triisopropyl borate → 3-Fluoro-4-methoxyphenylboronic acid

Participants

Reaction Steps

The title compound was prepared by reacting 4-bromo-2-fluoroanisole (10 g, 0.049 mol) with n-butyl lithium (23.4 mL of 2.5 M solution in hexane, 0.059 mol) followed by triisopropyl borate (45.2 mL, 36.9 g, 0.196 mol) according to method F to yield 7.1 g (85.2%) of a white solid: MS (ESI) m/z 169 (M−H)−: 1H NMR (DMSO-d6): δ 3.84 (3H, s), 7.10–7.16 (1H, m), 7.51–7.60 (2H, m).

Provenance & Evidence