Aminopyrazine → HCID 21034118, compound

HRID 1830705Notes

Reaction equation

HRID 1830705 reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=[O:12].[NH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>COC(OC)C>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]([NH:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1)=[O:12]

Participants

4

Reactant 2

HCID 78747AminopyrazineHCID 27333702-(Difluoromethoxy)phenyl isocyanate

Product 1

HCID 21034118HCID 21034118, compound

Reagents, catalysts & solvents 1

HCID 107951,1-DimethoxyethaneSolvent

Procedure

2-(Difluoromethoxy)phenylisocyanate (1.0 g, 5.4 mmol) and aminopyrazine (0.51 g, 5.4 mmol) were reacted for 6 hours in refluxing dimethoxy-ethane (20 mL). The reaction mixture was cooled to room temperature to precipitate the product, which was collected by filtration, washed with ethyl acetate, and dried in vacuo (765 mg, 50%). 1H NMR (300 Mhz, d6-DMSO) δ: 10.49 (br s, 1H), 10.26 (s, 1H), 8.83 (s, 1 H), 8.35-8.24 (m, 3H), 7.53-7.00 (m,4H).

Workup

  1. customto precipitate the product, which
  2. filtrationwas collected by filtration
  3. washwashed with ethyl acetate
  4. customdried in vacuo (765 mg, 50%)

Sources & evidence

ORD record
ord-8bade298c37f4494952610cff70ad717
Source dataset
uspto-grants-2006_06
Patent number
US07067506B2

Reaction notes

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