HuagongsheHuagongshe Chemistry Print Report · For research reference only
P,P-Diphenylphosphinic azide → 1-(4-Dimethylaminomethyl-2-methoxy-phenyl)-3-(5-methyl-pyrazin-2-yl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | (5-Methyl-pyrazin-2-yl)-urea | HCID 22046266 | — |
| Reactant | 4-((Dimethylamino)methyl)-2-methoxyaniline | HCID 22046286 | — |
| Product | 1-(4-Dimethylaminomethyl-2-methoxy-phenyl)-3-(5-methyl-pyrazin-2-yl)-urea | HCID 22046498 | — |
Reaction Steps
According to the diphenylphosphoryl azide method described above for compound 336, 4-dimethylaminomethyl-2-methoxy-phenylamine was converted to the (5-methyl-pyrazin-2-yl)-urea. The crude product was purified by preparative TLC, eluting with 5% MeOH in CH2Cl2. 1H NMR (400 MHz, d6-DMSO): δ11.21 (s, 1H), 8.95 (s, 1H), 8.39 (s, 1H), 8.21 (d, J=7.83 Hz, 1H), 8.04 (s, 1H), 7.01 (s, 1H), 6.89 (d, J=7.83 Hz, 1H), 3.98 (s, 3H), 3.92 (s, 2H), 2.26 (s, 3H), 2.24 (s, 6H). MS APCI-Pos, M+1=316.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067506B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-57005d5dcb4e4dcaa7d8240269081724 |
| Source note | uspto-grants-2006_06 |