Ammonium Hydroxide → HCID 22048459, compound

Participants

Reaction Steps

A mixture of intermediate (10)(0.0065 mol) in HCl 3N (100 ml) and THF (100 ml) was stirred and refluxed for 6 hours. The mixture was poured out on ice, alkalized with a concentrated NH4OH solution and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated till dryness, yielding 3 g (>100%) of 4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)-2-thiazolylmethyl]-2(1H)-quinolinone (intermediate 11).

Provenance & Evidence