HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1830803Generated: November 1, 2026
3-(3-Chlorophenyl)-alpha-(4-phenyl-2-thiazolyl)-2,1-benzisoxazole-5-methanol → HCID 22048460, compound
https://huagongshe.com/reaction/1830803
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(3-Chlorophenyl)-alpha-(4-phenyl-2-thiazolyl)-2,1-benzisoxazole-5-methanol | HCID 22048477 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 22048460 | HCID 22048460 | 100% |
Reaction Steps
A mixture of intermediate (14) (0.0656 mol) and MnO2 (27.5 g) in 1,4-dioxane (275 ml) was stirred at 80° C. for 3 hours, then cooled to room temperature, filtered over celite and pasted up with CH2Cl2/CH3OH. The solvent was evaporated till dryness, yielding 27.3 g (100%) of [3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl](4-phenyl-2-thiazolyl)-methanone (intermediate 15).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07067531B2 |
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| Source dataset | uspto-grants-2006_06 |
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| ORD ID | ord-d72d3f3bb9c442be9700e0c7f5b3bb0b |
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| Source note | uspto-grants-2006_06 |
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