Methyl iodide → HCID 22048482, compound

Participants

Reaction Steps

A mixture of intermediate (21) (0.0132 mol), iodomethane (0.0264 mol) and benzyltriethylammonium chloride (0.00132 mol) in THF (50 ml) and sodium hydroxide 10N (50 ml) was stirred at room temperature overnight. EtOAc was added. The mixture was decanted. The organic layer was dried, filtered and the solvent was evaporated. The residue (2.9 g) was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH/NH4OH 95/5/0.1; 15–40 μm). The pure fractions were collected and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: toluene/2-propanol/NH4OH 70/29/1; 15–40 μm). The pure fractions were collected and the solvent was evaporated. The residue was crystallized from diethyl ether. The precipitate was filtered off and dried, yielding 0.45 g of 4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone, mp. 167° C. (intermediate 22).

Provenance & Evidence