Sodium borohydride → HCID 10225227, compound

Participants

Reaction Steps

To a mixture solution of the compound (10) obtained in the Example 10 in methanol was added 1.0 equivalent of sodium borohydride at 0° C., and the mixture was stirred for 1.5 hours at the room temperature. After the reaction, the solvent was removed under reduced pressure, and the resulting residue was purified by amine-coated silica gel (Fuji Silysia Chemical Ltd.) column chromatography (dichloromethane : methanol =20:1) to give the above-mentioned compound (11) in the yield of 58%.

Provenance & Evidence