Hydrogen Peroxide → HCID 10115004, compound

Participants

Reaction Steps

To a mixture solution of 82 mg of the compound (18) obtained in the Example 18 in methanol were added 58 μl of 30% hydrogen peroxide aqueous solution and 150 μl of 3N-sodium hydroxide aqueous solution under ice-cooling, and the reaction mixture was stirred for 6 hours at the room the temperature. After the reaction, saturated sodium hydrogen carbonate aqueous solution was added to the reaction mixture, and extracted with dichloromethane. The organic layer was washed with saturated saline, dried and the solvent was removed under reduced pressure. The resulting residue was purified by amine coated silica gel (Fuji Silysia Chemical Ltd.) column chromatography (dichloromethane : methanol =10:1) to give 66 mg (77%) of the above-mentioned compound (19).

Provenance & Evidence