Thionicotinamide → HCID 22049723, compound

HRID 1830886Notes

Reaction equation

HRID 1830886 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[C:12]([NH2:20])(=[S:19])[C:13]1[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=1>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:20]=[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:19][CH:2]=1

Participants

3

Reactant 2

HCID 737155ThionicotinamideHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049723HCID 22049723, compoundYield 39.5%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (432 mg) and thionicotinamide (152 mg), the title compound (110 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-8d9b41d4397d4d188d3dd4e000bc0f14
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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