4-Pyridinecarbothioamide → HCID 22049802, compound

HRID 1830887Notes

Reaction equation

HRID 1830887 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[C:12]([NH2:20])(=[S:19])[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:20]=[C:12]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[S:19][CH:2]=1

Participants

3

Reactant 2

HCID 27237884-PyridinecarbothioamideHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049802HCID 22049802, compoundYield 27.5%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (428 mg) and thioisonicotinamide (153 mg), the title compound (77 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-505e4386fb5c46aeaba5b5a6854d97d2
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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