HCID 22049764, compound → HCID 22049675, compound

HRID 1830892Notes

Reaction equation

HRID 1830892 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[CH3:12][N:13]1[CH2:21][C:20]2[C:19]([C:22](=[S:24])[NH2:23])=[CH:18][CH:17]=[CH:16][C:15]=2[C:14]1=[O:25]>>[CH3:12][N:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][C:19]=2[C:22]2[S:24][CH:2]=[C:3]([C:5]3[CH:6]=[N:7][CH:8]=[CH:9][C:10]=3[CH3:11])[N:23]=2)[C:14]1=[O:25]

Participants

3

Reactant 2

HCID 22049764HCID 22049764, compoundHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049675HCID 22049675, compoundYield 24.9%

Procedure

By the reaction in the same manner as in Example 25-ii) using 2-methyl-1-oxo-4-isoindolincarbonitrile (364 mg), crude 2-methyl-1-oxoisoindolin-4-carbothioamide (603 mg) was obtained as a brown powder. Then, by the reaction in the same manner as in Example 25-iii), 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (500 mg) and 2-methyl-1-oxoisoindolin-4-carbothioamide (520 mg), the title compound (187 mg) was obtained as colorless powder crystals.

Sources & evidence

ORD record
ord-9220d9f76f0a4292bf3ed739e469ad13
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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