HCID 22049741, compound → HCID 135819832, compound

HRID 1830893Notes

Reaction equation

HRID 1830893 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.C([O:16][C:17]1[N:22]=[CH:21][C:20]([C:23](=[S:25])[NH2:24])=[CH:19][CH:18]=1)(C)(C)C>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:24]=[C:23]([C:20]2[CH:19]=[CH:18][C:17](=[O:16])[NH:22][CH:21]=2)[S:25][CH:2]=1

Participants

3

Reactant 2

HCID 22049741HCID 22049741, compoundHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 135819832HCID 135819832, compoundYield 56.1%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (188 mg) and 6-tert-butoxy-3-pyridinecarbothioamide (167 mg), the title compound (120 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-b0ff831c3f2e4d68be988700ce5b541e
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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