HCID 22049712, compound → HCID 22049746, compound

HRID 1830894Notes

Reaction equation

HRID 1830894 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[CH3:12][O:13][C:14]1[N:19]=[C:18]([O:20][CH3:21])[C:17]([C:22](=[S:24])[NH2:23])=[CH:16][N:15]=1>>[CH3:12][O:13][C:14]1[N:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]2[S:24][CH:2]=[C:3]([C:5]3[CH:6]=[N:7][CH:8]=[CH:9][C:10]=3[CH3:11])[N:23]=2)=[CH:16][N:15]=1

Participants

3

Reactant 2

HCID 22049712HCID 22049712, compoundHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049746HCID 22049746, compoundYield 16.9%

Procedure

By the reaction in the same manner as in Example 25-ii) using 2,4-dimethoxy-5-pyrimidinecarbonitrile (1.32 g), crude 2,4-dimethoxypyrimidine-5-carbothioamide (1.92 g) was obtained as a brown powder. Then, by the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (1.07 g) and 2,4-dimethoxypyrimidine-5-carbothioamide (880 mg), the title compound (235 mg) was obtained as colorless powder crystals.

Workup

  1. customThen, by the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-df3f941a63544080bf884467167f8bfd
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

Loading…