3-Sulfamoylbenzene-1-carbothioamide → 3-[5-Methyl-4-(4-methylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 1830900Notes

Reaction equation

HRID 1830900 reaction equation
Br[CH:2]([CH3:12])[C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[NH2:13][S:14]([C:17]1[CH:18]=[C:19]([C:23](=[S:25])[NH2:24])[CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]>>[CH3:12][C:2]1[S:25][C:23]([C:19]2[CH:18]=[C:17]([S:14]([NH2:13])(=[O:15])=[O:16])[CH:22]=[CH:21][CH:20]=2)=[N:24][C:3]=1[C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11]

Participants

3

Reactant 2

HCID 51512363-Sulfamoylbenzene-1-carbothioamideHCID 220497622-Bromo-1-(4-methylpyridin-3-yl)propan-1-one

Product 1

HCID 220497343-[5-Methyl-4-(4-methylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamideYield 65.2%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)propan-1-one hydrobromate (520 mg) and 3-(aminosulfonyl)benzenecarbothioamide (361 mg), the title compound (376 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-68e61c40ec89417f868dc350961fbe27
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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