Dimethylamine → HCID 22049770, compound

HRID 1830904Notes

Reaction equation

HRID 1830904 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[C:22]([F:25])([F:24])[F:23])[S:14][CH:15]=2)=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)(Cl)=O.[CH3:30][NH:31][CH3:32]>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[C:22]([F:23])([F:25])[F:24])[S:14][CH:15]=2)=[CH:7][C:3]=1[C:4]([N:31]([CH3:32])[CH3:30])=[O:5]

Participants

4

Reactant 3

HCID 674DimethylamineHCID 24386Thionyl ChlorideHCID 22049750HCID 22049750, compound

Product 1

HCID 22049770HCID 22049770, compound

Procedure

By the reaction in the same manner as in Example 60 using 2-fluoro-5-{2-[4-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-4-yl}benzoic acid (201 mg), thionyl chloride (0.06 ml) and aqueous dimethylamine solution (50%, 5 ml), the title compound (90 mg) was obtained as a colorless amorphous compound.

Sources & evidence

ORD record
ord-433d864cb17a464d9f7757953f40164c
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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