Methyl iodide → 4-Isopropylnicotinonitrile

HRID 1830909Notes

Reaction equation

[CH2:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].[CH3:11]I>>[CH:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)([CH3:11])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 217660084-Ethylpyridine-3-carbonitrile

Product 1

HCID 220497534-Isopropylnicotinonitrile

Procedure

By the reaction in the same manner as in Example 64-i) using 4-ethylnicotinonitrile (2.95 g) and methyl iodide (7 ml), the title compound (1.90 g) was obtained as a yellow oil.

Workup

customBy the reaction in the same manner as in Example 64-i)

Sources & evidence

ORD record: ord-78d5e408f8294eeb843ffde4d1b37a8d
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067537B2

Reaction notes

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