Bromine → HCID 22049748, compound

HRID 1830910Notes

Reaction equation

HRID 1830910 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11])([CH3:3])[CH3:2].[Br:13]Br>>[Br:13][CH2:11][C:10]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:4]=1[CH:1]([CH3:3])[CH3:2])=[O:12]

Participants

3

Reactant 2

HCID 24408BromineHCID 220497721-[4-(1-Methylethyl)-3-pyridinyl]ethanone

Product 1

HCID 22049748HCID 22049748, compound

Procedure

By the reaction in the same manner as in Example 53-ii) using 1-(4-isopropylpyridin-3-yl)ethanone (0.90 g) and bromine (0.63 g), crude 2-bromo-1-(4-isopropylpyridin-3-yl)ethanone hydrobromate (1.70 g) was obtained as a pale-brown amorphous compound. Then, by the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-isopropylpyridin-3-yl)ethanone hydrobromate (340 mg) and 3-(aminocarbonothionyl)benzamide (240 mg), the title compound (59 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 53-ii)

Sources & evidence

ORD record
ord-53db1df010a7401983f560cfae514c99
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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