2-Methyl-5-nitrobenzenecarbothioamide → HCID 22049688, compound

HRID 1830913Notes

Reaction equation

HRID 1830913 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=1[C:22](=[S:24])[NH2:23]>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:23]=[C:22]([C:14]2[CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=[CH:18][C:13]=2[CH3:12])[S:24][CH:2]=1

Participants

3

Reactant 2

HCID 220497162-Methyl-5-nitrobenzenecarbothioamideHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049688HCID 22049688, compound

Procedure

By the reaction in the same manner as in Example 25-ii) using 2-methyl-5-nitrobenzonitrile (1.25 g), 2-methyl-5-nitrobenzenecarbothioamide was obtained as a yellow powder. Then, by the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (1.35 g) and 2-methyl-5-nitrobenzenecarbothioamide, the title compound (460 mg) was obtained as colorless needle crystals.

Workup

  1. customThen, by the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-fa360708756542308c95bf395d23f218
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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