3-(2-Bromoacetyl)benzonitrile → HCID 22049693, compound

HRID 1830914Notes

Reaction equation

HRID 1830914 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=O.[CH3:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:20](=[S:22])[NH2:21]>>[CH3:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:20]1[S:22][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=2)[C:8]#[N:9])[N:21]=1

Participants

3

Reactant 2

HCID 27358673-(2-Bromoacetyl)benzonitrileHCID 220497214-Methylpyridine-3-carbothioamide

Product 1

HCID 22049693HCID 22049693, compoundYield 41.1%

Procedure

By the reaction in the same manner as in Example 25-iii) using 3-(bromoacetyl)benzonitrile (599 mg) and 4-methylpyridine-3-thiocarboxamide (403 mg), the title compound (302 mg) was obtained as pale-yellow powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-287df9f321e34690b32edb16964aeb2f
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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