3-(2-Bromoacetyl)benzonitrile → HCID 22049799, compound

HRID 1830915Notes

Reaction equation

HRID 1830915 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=O.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21](=[S:23])[NH2:22]>>[F:24][C:14]([F:13])([F:25])[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21]1[S:23][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=2)[C:8]#[N:9])[N:22]=1

Participants

3

Reactant 2

HCID 27358673-(2-Bromoacetyl)benzonitrileHCID 27777714-(Trifluoromethyl)pyridine-3-carbothioamide

Product 1

HCID 22049799HCID 22049799, compoundYield 76.3%

Procedure

By the reaction in the same manner as in Example 25-iii) using 3-(bromoacetyl)benzonitrile (913 mg) and 4-trifluoromethylpyridine-3-thiocarboxamide (840 mg), the title compound (1.03 g) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-5016d9c24c124e298d1abe604194ae58
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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