Dimethylamine → HCID 22049778, compound

HRID 1830924Notes

Reaction equation

HRID 1830924 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=2)[C:16]([OH:18])=O)[N:12]=1.S(Cl)(Cl)=O.[CH3:26][NH:27][CH3:28]>>[CH3:26][N:27]([CH3:28])[C:16](=[O:18])[C:15]1[CH:19]=[CH:20][CH:21]=[C:13]([C:11]2[N:12]=[C:8]([C:3]3[CH:4]=[N:5][CH:6]=[CH:7][C:2]=3[CH3:1])[S:9][CH:10]=2)[CH:14]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 24386Thionyl ChlorideHCID 22049703HCID 22049703, compound

Product 1

HCID 22049778HCID 22049778, compound

Procedure

By the reaction in the same manner as in Example 60 using 3-[2-(4-methylpyridin-3-yl)-1,3-thiazol-4-yl]benzoic acid (248 mg), thionyl chloride (0.09 ml) and aqueous dimethylamine solution (50%, 5 ml), the title compound (200 mg) was obtained as colorless powder crystals.

Sources & evidence

ORD record
ord-68d29f83a57e41aeb4add13b3fdeec63
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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