HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → HCID 22049881, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 4-Cyclopropylbenzene-1-sulfonyl chloride | HCID 22049882 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22049881 | HCID 22049881 | 97% |
Reaction Steps
Crude compound 45 (13.3 g) was dissolved in 200 mL of acetone and 60 mL of water. Potassium fluoride (7.12 g, 122 mmol) was added and the reaction mixture was stirred overnight at rt. The reaction mixture was diluted with EtOAc and washed with water. The organic layer was dried with Na2SO4, filtered, and concentrated to dryness to give 9.80 g (97%) of crude p-cyclopropyl benzenesulfonyl fluoride (Compound 46).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067539B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-742ff3e8909c4e08b0bb6e3d82f1effe |
| Source note | uspto-grants-2006_06 |