HCID 10204107, compound → HCID 10136447, compound

Participants

Reaction Steps

A solution of 2-[4-pyridinylmethyl]amino-N-[4-[(Z)-1-propenyl]-3-(trifluoromethyl)phenyl]benzamide (Example 8; 0.80 g, 1.75 mmol) in methanol (25 mL) is hydrogenated at atmospheric pressure over 5% platinum on carbon (0.2 g) at 22° C. The calculated amount of hydrogen is taken up after 12 hours. The mixture is then filtered and the solvent is evaporated under reduced pressure to yield the crude product which is purified by column chromatography on silica gel, eluent 20% dichloromethane in EtOAc and recrystallised from diethylether-hexane to give the title compound as a colourless crystalline solid; m.p. 134–135° C.

Provenance & Evidence