反应详情

温度

190 °C

A mixture of 1-(5-methoxy-pyrimidin-2-yl)-4,4-dimethyl-piperidine-2,6-dione (0.99 g, 3.97 mmol) and pyridine hydrochloride (1.50 g, 7.99 mmol) was heated at 190° C. for 2.5 hours. After cooling to room temperature the reaction mixture was dissolved in a small amount of dichloromethane and filtered over a short pad of silicagel and washed with ethyl acetate. Evaporation of the solvent in vacuo yielded the title compound (0.60 g, 64% yield) as a white solid.

1. temperatureAfter cooling to room temperature the reaction mixture
2. filtrationfiltered over a short pad of silicagel
3. washwashed with ethyl acetate
4. customEvaporation of the solvent in vacuo