Thionyl Chloride → HCID 22047722, compound

HRID 1831069Notes

Reaction equation

HRID 1831069 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][CH2:13][CH2:14][C:15]([Cl:17])=[O:16])=[O:11])=[CH:5][CH:4]=1.S(Cl)(Cl)=O>ClCCl>[ClH:17].[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:15](=[O:16])[CH2:14][CH2:13][CH2:12][C:10]2=[O:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22047823HCID 22047823, compound

Product 1

HCID 22047722HCID 22047722, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The crude 4-(6-methoxy-pyridin-3-ylcarbamoyl)-butyryl chloride was redissolved in dichloromethane (25 mL). Thionyl chloride (5.95 g, 50 mmol) was added and the solution was heated to reflux overnight. The solvent and excess thionyl chloride were evaporated in vacuo, yielding 6′-methoxy-4,5-dihydro-3H-[1,3′]bipyridinyl-2,6-dione hydrochloride, which was used without further purification.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvent and excess thionyl chloride were evaporated in vacuo

Sources & evidence

ORD record
ord-c3b5fb3972fa48fb95cb565919c54012
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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