関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridinium chloride | HCID 10176127 | — |
| 反応物 | Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)- | HCID 22047745 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]- | HCID 178516274 | 68% |
反応手順
A mixture of 2-methoxy-5-(5-trifluoromethyl-pyridin-2-yloxy)-pyridine (0.28 g, 1.04 mmol) and pyridine hydrochloride (1.00 g, 8.65 mmol) was heated in a kugelrohr oven at 200° C. for 10 minutes. After cooling to room temperature, the reaction mixture is dissolved in dichloromethane and extracted with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound (180 mg, 68% yield) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07067517B2 |
|---|
| 出典データセット | uspto-grants-2006_06 |
|---|
| ORD ID | ord-fc869a2efc724db9817acdd4c72124b4 |
|---|
| 出典メモ | uspto-grants-2006_06 |
|---|
