Pyridinium chloride → HCID 178516278, compound

HRID 1831074Notes

Reaction equation

HRID 1831074 reaction equation
[Cl:1][C:2]1[C:3]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16]C)=[N:14][CH:15]=2)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.N1C=CC=CC=1>ClCCl.O>[Cl:1][C:2]1[C:3]([O:9][C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[N:14][CH:15]=2)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 2

HCID 10176127Pyridinium chlorideHCID 22047840HCID 22047840, compound

Product 1

HCID 178516278HCID 178516278, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
200 °C

Procedure

A mixture of 5-(3,5-dichloro-pyridin-2-yloxy)-2-methoxy-pyridine (2.39 g, 8.82 mmol) and pyridine hydrochloride (7.00 g, 60.6 mmol) was heated in a kugelrohr apparatus at 200° C. for 25 minutes. After cooling to room temperature dichloromethane and water were added. The solid material, which was insoluble in dichloromethane and water, was isolated by suction and dried in a vacuum oven at 45° C., yielding the title compound, which was used without further purification.

Workup

  1. additionwere added
  2. customdried in a vacuum oven at 45° C.

Sources & evidence

ORD record
ord-8b5ed5da739f444ebdcd0ed5488a107b
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

Loading…