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Phosphate → Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphate | HCID 1061 | — |
| 反応物 | Carbamic chloride, N-methyl-N-phenyl- | HCID 77969 | — |
| 反応物 | 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]phenol | HCID 605504 | — |
| 生成物 | Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester | HCID 10172371 | — |
反応手順
The title compound was prepared from 4-(4-chloromethyl-thiazol-2-yl)-phenol and N-methyl-N-phenylcarbamoyl chloride. The aqueous phase was adjusted to PH 7.0 (phosphate buffer) before extraction with ethyl acetate. The crude product was subjected to preparative HPLC (21%, white crystals). HPLC-MS m/z=359.0 (M+1), Rt: 4.60.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07067517B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-5baaf7edaa4b4e028643d510fc725e02 |
| 出典メモ | uspto-grants-2006_06 |