HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → 3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol | HCID 155241 | — |
| Reactant | 3-methyl-1-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-imidazol-3-ium iodide | HCID 22047918 | — |
| Product | 3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester | HCID 23635514 | — |
Reaction Steps
The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was recrystallized (ethanol) (53%). HPLC-MS m/z=415.2 (M+1), Rt: 5.3 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067517B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-c5913d71c38a47cd8fc665c43ceb4ce6 |
| Source note | uspto-grants-2006_06 |